Access is designed to accommodate multiple users in the system at the same time but there are some tasks that require you to open the database in exclusive mode. So that nobody other can use it while you are accessing it.
You may need to have exclusive access to the databse to either to modify forms, tables etc. or while at the time of changing the password of an access database or while adjusting other security settings. Access might remind you to open the database in exclusive mode. Here is the complete step for opening up an access database exclusively.
Navigate for the file and select it.
You can't do changes to the database information in read only mode but can make security changes that will stick after saving.